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Shi Yunyu, an 80-year-old academician of the Chinese Academy of Sciences and a professor at the School of Life Sciences of the Chinese University of Science and Technology —— Pursuing the mystery of b

　　Shi Yunyu is in the office. Photo courtesy of respondents

　　Character business card

　　Shi Yunyu: Academician of China Academy of Sciences, biophysicist and structural biologist, professor and doctoral supervisor of China University of Science and Technology. Born in Chongqing in April 1942, she was admitted to the Department of Biophysics of the Chinese University of Science and Technology in 1960. Since then, she has formed an indissoluble bond with life science. Over the years, Shi Yunyu has been sticking to the front line of scientific research, using structural biology methods to study the molecular mechanism of gene expression regulation and cell fate determination, and has made many innovative achievements, making contributions to China’s biological nuclear magnetic resonance research in the world.

　　Dressed in a cloth and with silver hair, Shi Yunyu clicked the mouse neatly in the office, and the three-dimensional structure of protein jumped into his eyes: "The world of biomacromolecules is full of unknowns. We have encountered many difficulties and challenges in the research process, but we must not give up lightly." Shi Yunxi said.

　　My father’s words and deeds, what he saw and heard on his way to school, let the seeds of scientific research serve the country take root.

　　Shi Yunyu has always had a scientific research dream! Whether she leaned against her father when she was young, listened to him describe the colorful physical world, or came into contact with the frontier of life science on the long way to school, the idea of serving the country through scientific research always lingered in her mind … …

　　Shi Yunyu was born in the era of war. The experience of being displaced as a child made her realize that personal destiny is always closely linked with the destiny of the country and the nation. Father Shih-Yuan Sze is a doctor of physics under the guidance of Madame Curie. After graduation, Shih-Yuan Sze, then 25, returned to China to teach and became one of the pioneers of nuclear physics research and higher education in China. In Shi Yunyu’s view, the spirit of serving the country through scientific research is vividly displayed in his father; His words and deeds also inspired Shi Yunyu’s enthusiasm for scientific research.

　　With a passion for natural science, Shi Yunyu was admitted to China University of Science and Technology in 1960. At that time, biophysics was a new discipline and the education system was not yet mature. "Academician Bei Shizhang, then head of the biophysics department of the Chinese University of Science and Technology, believed that the curriculum should be ‘ Four unlike ’ Let students lay a good foundation in mathematics, physics, chemistry and biology. " Shi Yunyu said that it is the solid basic course study that lays a solid foundation for his future scientific research work.

　　In the classroom, the days when scholars such as Qian Xuesen, Hua Luogeng and Yan Jici gave lectures to everyone made her remember vividly … … Shi Yunyu said: "How fortunate to be able to feel the deep patriotic feelings of the older generation of scientists at close range!" In the auditorium, everyone gathered around a black-and-white TV set and rejoiced at the China athletes winning the world table tennis championship. She still can’t forget it: "When I was young, everyone’s enterprising state always inspired me and made me determined to contribute to the construction of the motherland with my own scientific research results."

　　After graduating from college, Shi Yunyu was first assigned to work in the former Institute of Traditional Chinese Medicine of the Ministry of Health; In 1970, she returned to China University of Science and Technology to teach, and before long, she moved south from Beijing to Hefei, Anhui.

　　Shi Yunyu undertook the task of relocating instruments and equipment to the south. Together with her colleagues, she moved boxes full of equipment from the teaching building to the station in Beijing, and then moved them from the station to the teaching building … …

　　Engaged in computer molecular dynamics simulation of biological macromolecules earlier; Leading the establishment of the key laboratory of structural biology of Chinese Academy of Sciences

　　The southward migration of China University of Science and Technology has gone through hardships, with the loss of scientific research equipment and weak teaching strength … … "Fortunately, the school later took a series of new measures and gradually got on the right track." Shi Yunyu said that the school provided opportunities for young teachers to go abroad for further study, and she became the first young teacher in the Biology Department of the Chinese University of Science and Technology to pass the examination of the Ministry of Education. She went abroad twice for further study, engaged in computational biology research and biological nuclear magnetic resonance spectroscopy research, and learned the theoretical and experimental methods of studying the structure and function of biological macromolecules with molecular dynamics and two-dimensional nuclear magnetic resonance spectroscopy. Shi Yunyu said: "The experience of studying abroad has broadened my scientific research horizons and urged me to work harder to acquire knowledge."

　　In the 1970s, Shi Yunyu and his colleagues were eager to keep up with the pace of international academic circles and carry out cutting-edge research on biomacromolecules in the University of Science and Technology of China, but they lacked funds and instruments. In order to promote the project quickly, Shi Yunyu and his colleagues went all over the library in Shanghai, searched for literature and materials, and racked their brains for two weeks before finishing the application for the National High-tech Research and Development Plan.

　　At that time, there were three subjects selected by the Biology Department of the Chinese University of Science and Technology, and the "New Technology Research of Molecular Design in protein" which Shi Yunyu was in charge of was one of them. Since then, she began to engage in computer molecular dynamics simulation of biological macromolecules and became one of the pioneers in this field in China. The project "Computer Simulation of Biomolecular Structure and Dynamics" led by Shi Yunyu won the second prize of the Natural Science Award of China Academy of Sciences in 1996 and the third prize of the National Natural Science Award in 1999.

　　In the early 1990s, Shi Yunyu’s laboratory was supported by the Chinese Academy of Sciences and bought the first 500 MHz nuclear magnetic resonance spectrometer, which can be used for the solution structure of biological macromolecules. However, when the experiment was really carried out, there were still many difficulties … … Her attitude is firm: "scientific research should be devoted, able to withstand loneliness and twists and turns." The research group led by Shi Yunyu analyzed the solution structures of a series of important protein, and revealed the protein interaction and its functional significance. She also led the establishment of the Key Laboratory of Structural Biology of Chinese Academy of Sciences, and later became an important part of Hefei National Research Center for Microscale Material Science.

　　Do popular science for primary and secondary school students, teach basic courses for undergraduates, and train more young scientific research talents.

　　Shouxian County, Anhui Province, No.1 Middle School. On the stage, Shi Yunyu held a microphone and explained his own experience and knowledge of life science. Under the stage, the students were absorbed and deeply attracted by the biomacromolecule world she described. From the stimulation of scientific interest to the choice of scientific research direction, from laying a solid foundation to the enthusiasm of serving the country, in an hour and a half, Shi Yunyu planted the seeds of science in the hearts of children … …

　　Although he is 80 years old, Shi Yunyu still walks into primary and secondary schools many times to give lectures on popular science to students. "Being exposed to scientific knowledge since childhood has aroused my curiosity and embarked on the road of scientific research; I also want to pass this enthusiasm on to the children. " Shi Yunyu hopes to open a window of science for children.

　　Shi Yunyu remembers: In 2019, at Huangtugang Town Central Primary School in Macheng, Hubei Province, she gave a popular science class on "Hemoglobin and Hemoglobin Diseases" to children in Dabie Mountains. Her classmates’ eyes are full of thirst for scientific knowledge, which deeply touched her, so she likes to go out of campus and go to the mountains … …

　　In the College of Life Sciences of the Chinese University of Science and Technology, in order to strengthen the basic education of undergraduates, Shi Yunyu insisted on giving general biology classes to freshmen for many years. Shi Yunyu said that for interdisciplinary subjects, basic courses are very important. "Teaching is the bounden duty of teachers, and I want to train more talents for science." As the first dean of the School of Life Sciences of the Chinese University of Science and Technology, together with her colleagues, she took the lead in establishing a complete teaching system of structural biology and computational biology in the Chinese University of Science and Technology, and specially invited experts from the Institute of Biophysics of the Chinese Academy of Sciences to teach students and trained a group of young academic leaders working in interdisciplinary fields such as computational biology and structural biology.

　　Today, with her silver hair, she still rushes to work in the laboratory every day. In school, when she meets Shi Yunyu, the students always call her "Grandma Shi" in a friendly way. At present, "Grandma Shi" has begun to study the structure of protein related to aging and degenerative diseases and the molecular and cellular mechanism of diseases. In addition, she is actively promoting the research of artificial intelligence and biomedicine. She believes that every new field has a lot of knowledge to learn, and the happiness of mountaineering is not only the moment when you reach the top of the mountain, but also in the process of continuous climbing.

　　■ Reporter’s Notes

　　Research never stops, only lifelong learning.

　　During the interview, Shi Yunyu was full of interest when he mentioned the frontier development in the field of life sciences … … At the age of 80, she is willing to study with young people while cultivating scientific research talents. In Shi Yunyu’s view, being able to explore the mysteries of the biomacromolecule world with students is both happy and fulfilling. Young people always learn new things faster, and they can experience the taste of being a student when they meet something she doesn’t quite understand.

　　Life science is closely related to population health, medicine and ecology, and the life world is full of many unsolved scientific problems. For Shi Yunyu, research never stops, only lifelong learning. It is countless scientists, like her, who keep their enthusiasm for learning and keep climbing up, which makes scientific research full of vitality … …

Disease is rare, care is rare-China has taken a key step to solve the problem of rare diseases

Xinhua News Agency, Beijing, February 27th Title: Diseases are rare, and care is rare-China has taken a key step to solve the problem of rare diseases.

Xinhua News Agency reporters Chen Fang and Tian Xiaohang

It was a nightmare disaster. From the age of 1 to 16, Wang Yiou suffered six fractures.

The 37-year-old Yiou has beautiful and clear blue eyes. People familiar with the disease know that this is one of the typical symptoms of brittle bones patients known as "porcelain dolls": blue sclera.

Behind the seemingly beautiful but shocking names of "Puppet Man" and "Glass Man" are life killers-rare diseases. The last day of February every year is the International Day of Rare Diseases. In China, more than 20 million patients with rare diseases, including gulls, have attracted more and more attention from all walks of life.

Although diseases are rare, social care is rare. Following the price reduction of some anticancer drugs and medical insurance, "ensuring the use of drugs for 20 million patients with rare diseases" was put on the agenda. The establishment of China Rare Diseases Alliance and the preferential treatment of value-added tax for rare diseases drugs … China has made a key step to solve the problem of rare diseases.

How many patients do you have? Without ice bucket action, would you know about gradual freezing?

Hawking, a famous physicist who died of illness last year, struggled with gradual freezing for 55 years. A relay ice bucket challenge made more people know about this rare disease called amyotrophic lateral sclerosis. At present, there are about 200,000 patients with gradual freezing in China.

Ding Jie, member of Chinese People’s Political Consultative Conference and chairman of the rare diseases branch of Beijing Medical Association, has been devoted to the research, diagnosis and treatment of rare diseases in recent years. Since 2013, its team has collected more than 400,000 inpatient medical records of rare diseases in more than 30 3A hospitals in Beijing in the past five years, and found that the incidence of patients with rare diseases is increasing year by year. Studies show that more than 80% of rare diseases are caused by genetic factors, and 50% occur at birth or in childhood. Once both spouses have the same defective gene, the next generation may suffer from rare diseases.

High misdiagnosis, high missed diagnosis and difficulty in medication are common "symptoms" of patients with rare diseases. The survival report of patients with multiple sclerosis published by the Neurology Branch of Chinese Medical Association shows that 47% of patients cannot be diagnosed immediately, and 38% of patients are misdiagnosed as other diseases. The most commonly misdiagnosed diseases are neuromyelitis optica and angiopathy.

There is no symptomatic medicine, the drug price is too high, and medical insurance is difficult to cover, which makes some patients with rare diseases "hope for medicine."

Zhang Shuyang, secretary-general of China Rare Diseases Alliance and vice president of Peking Union Medical College Hospital, said that less than 5% of rare diseases in the world have effective drug treatment. There is no medicine available, which is a big problem facing patients with rare diseases all over the world.

Ding Jie cited a survey of 2133 patients with more than 20 rare diseases, which showed that 78% of the patients could only be reimbursed less than 10% or paid at their own expense, and more than six of them gave up treatment because they could not afford the expenses.

"China has a large population base. Even if the incidence rate is not high, the number of cases of various diseases is not a small number." Zhan Qimin, academician of China Academy of Engineering and director of peking university health science center, said that 10 years ago, few people knew about rare diseases in China. Nowadays, with the joint efforts of the government, social organizations, doctors, medical research institutions and pharmaceutical companies, rare diseases are beginning to "stand in the spotlight" more and more.

How difficult is the treatment? 130 patients with Gaucher’s disease were treated in 10 years, with a total investment of 1.3 billion yuan.

The variety and complex clinical manifestations make it difficult to diagnose, which is another difficult problem in the diagnosis and treatment of rare diseases. Even some patients with rare diseases took twenty or thirty years to be diagnosed.

As a rare disease, multiple sclerosis is a serious, lifelong, progressive and disabling central nervous system disease. More than 30,000 patients are suffering, but many people didn’t know that they were suffering from this "lifelong" disease at first.

The research and development cycle of a new drug for rare diseases is usually more than 10 years. As of 2016, there are 189 kinds of orphan drugs listed in China to treat rare diseases, which is far from meeting the treatment needs compared with as many as 6,000 to 8,000 kinds of rare diseases.

Gaucher’s disease, which is "as big as a drum" and causes damage to the central nervous system, costs millions of yuan a year for its treatment, which is undoubtedly astronomical for an ordinary family. "It is a miracle to help 134 patients with Gaucher’s disease receive treatment so that they can work and live normally, and some of them are married and have children." Wang Shufeng, executive vice president of china charity federation, said that since the launch of the Sizanzan aid project for Gaucher’s disease in china charity federation in 2009, more than 57,000 aid drugs worth more than 1.3 billion yuan have been distributed.

Experts pointed out that rare diseases involve hematology, orthopedics, nerves, kidneys, respiration, skin and severe diseases, and clinicians generally lack professional knowledge of rare diseases. In China, more than 30% of patients with rare diseases need 5 to 10 doctors for diagnosis, and the scientific diagnosis process, related clinical pathways and multidisciplinary consultation mechanism need to be improved.

"It is impossible to ask all doctors to treat rare diseases, but at least let them have this awareness." Ding Jie said that when encountering certain symptoms, as long as we can think of the possibility of rare diseases and recommend patients to medical institutions with diagnosis and treatment capabilities in time, it is an improvement.

How practical is the measure: bringing good news to more than 20 million patients with rare diseases.

The recent the State Council executive meeting pointed out that "strengthening the prevention and treatment of major diseases such as cancer and rare diseases is related to the well-being of hundreds of millions of people".

The head of the Medical Administration and Hospital Authority of the National Health and Wellness Commission said that China will further promote the institutionalization and standardization of the management of rare diseases, study and explore new ways to promote the standardized diagnosis and treatment of rare diseases, improve the level of disease diagnosis and treatment and new drug research and development, and strive to provide timely and efficient medical services for patients with rare diseases.

"We should explore multidisciplinary cooperation, promote early diagnosis and treatment of rare diseases, and strive to reduce mortality." Zhang Shuyang revealed that China plans to initially complete the national rare disease registration system by 2020, carry out more than 500 kinds of rare diseases registration research with 50,000 cases, and promote data sharing research.

Accelerate the listing of "orphan drugs". At present, the application for registration of rare disease drugs has been given priority review and approval. People expect more innovative drugs to bring good news to patients.

It is preferred to select rare diseases with urgent clinical needs and clear treatment plans, which can greatly reduce the disability rate and mortality. Experts call for the establishment of a multi-party rescue model to solve the dilemma of diagnosis, treatment and medication for patients with rare diseases.

Requirements for the selection of ＂National Day Panda＂： Round mouth and not grumpy.

A pair of twins live in a "home"

"National Day Panda" arrives at Beijing Zoo. Reporter Lai Renqiong photo

　　At about 19: 00 on April 29th, six National Day panda babies, with an average age of about one and a half years, successfully arrived at Beijing Zoo from Sichuan China Research Center for the Protection of Giant Pandas after a 10-hour long journey.

　　10-hour long journey

　　At 8 o’clock in the morning on the 29th, the reporter came to the Panda Garden in Bifengxia Base of China Conservation Giant Panda Research Center in Sichuan. It’s already crowded here. Six iron cages filled with baby pandas are arranged horizontally, and the breeders are feeding them fresh bamboo.

　　"This male baby is called Xiangge and was born on August 7, 2007." The breeder told the reporter. At this time, Xiangge, sitting in a cage, was embarrassed and humiliated, holding bamboo shoots in her hands and sending them to her mouth. After breakfast, they will be sent to Chengdu Shuangliu Airport by special bus and transferred to the 14: 00 flight to Beijing.

　　According to Zhang Hemin, director of Wolong Nature Reserve Administration and director of China Giant Panda Protection Research Center, the six giant pandas born in Wolong suffered a major earthquake before they were sensible, and they have undergone severe tests from breeding to management. In order to celebrate the 60th birthday of New China, strengthen the scientific research cooperation and popular science education of giant pandas, China Research Center for the Protection of Giant Pandas and Beijing Zoo jointly launched the activity of "Wolong Giant Panda Going to Beijing to Welcome National Day".

　　At 19 o’clock on the 29th, six giant pandas arrived at Beijing Zoo successfully. The reporter saw at the scene of Beijing Zoo that many staff members had been waiting in front of the Giant Panda Pavilion to welcome distinguished "guests" from afar with applause.

　　"The six giant pandas are in good condition as a whole, except for one who is slightly depressed, and the rest are in excellent condition." Zhang Jinguo, deputy director of Beijing Zoo, who made a special trip to Sichuan to welcome the pandas, said.

　　According to Zhang Jinguo, before boarding the plane, the breeder provided the giant panda with enough water and food, and the flight also specially added pressurization and oxygen supply equipment to the cargo hold where the giant panda was riding. At about 16: 30, the giant panda arrived at Beijing Capital International Airport. After some necessary inspection and quarantine, he arrived at Beijing Zoo around 19: 00.

　　Selected from 13 pandas

　　In the accommodation area of the Panda Pavilion, the newly settled pandas seem to have no strangeness to this brand-new home. Some of them walk leisurely in the house, and some begin to taste fresh bamboo with relish. The most exciting thing is that one pair of twins actually climbed to the roof along the railing in the house.

　　"The six giant pandas were selected from 13 pandas born in Wolong in 2007." Zhang Jinguo told reporters that the basic conditions of choice include beautiful appearance, such as round mouth and black and white coat color; Personality should be lively and pleasing; Good health, strong adaptability and so on. At the same time, the six giant pandas should be compatible, that is to say, none of them can be particularly grumpy.

　　At present, these six giant pandas have their own lovely names, namely: Huaao, Xiangge, Qingfeng, Jinyi, Shuiling and Wenyu, among which the first three are males and the last three are females.

　　Meeting with tourists on May 1 ST

　　In the accommodation area of the Giant Panda Pavilion, the reporter saw that the food for giant pandas in Beijing was very rich: golden wowotou, fresh bamboo, freshly washed carrots …

　　Beijing Zoo has made careful preparations for the giant pandas coming from afar, and set up a working group to be responsible for the disease prevention and daily feeding management of giant pandas coming to Beijing. In order to provide fresh and delicious bamboo for giant pandas, we specially increased the purchase from Henan, ensuring that six pandas have 150 kilograms of fresh bamboo and 12 kilograms of fresh bamboo shoots every day.

　　In order to provide a comfortable living environment for giant pandas, Beijing Zoo has thoroughly cleaned and disinfected seven animal houses and four sports grounds in the Panda Pavilion, overhauled the equipment and facilities in the pavilion, such as the shelving, cold storage and monitoring, re-paved the lawn in the exhibition hall, carried out the "enrichment" work, and added two new tire rings for giant pandas to play with.

　　At the same time, Wolong will send keepers to Beijing in batches to take care of the life of the giant panda. Huangshan, a Wolong breeder who arrived in Beijing with the giant panda on the same plane on the 29th, has been engaged in panda breeding since 2004. He told reporters that the exhibition hall of Beijing Zoo has a good environment, the dormitory conditions are good and the food is clean and hygienic. "I believe the giant panda will definitely live happily in his new home!"

　　After a day’s rest and adjustment on the 30th, six giant pandas will begin to meet with Beijing citizens and tourists on May 1st, and will initially stay in Beijing for one year. (Reporter Lai Renqiong, Wang Jianxin, Wei He)

Editor: Wang Jiaolong

36,900 PCs／2 configuration models Pentium Pony Long Life Edition officially launched.

[car home] ] On October 28th, we learned from the official FAW Pentium that its mini electric car-The Pentium Pony Long Life Edition was officially launched, and the new car was launched in two configurations, with prices of 36,900 and 39,900 respectively.. At the same time, at the scene, the official announced a joint cooperation with Xiaoma Baoli, a subsidiary of Hasbro brand, and released the first creative animation video of "(|) Xiaoma Baoli", and launched a limited-edition joint-name tidal model. It is understood that this car is produced in the brand-new energy factory of China FAW Yancheng Branch, and it is also the first model mass-produced in this factory. In addition, the official also announced the launch of five car buying gifts, such as 999 yuan limited time to grab a pony Baoli co-branded suit worth 2,599 yuan, replacement subsidy of 4,000 yuan or scrapping subsidy of 4,000 yuan, and vehicle lifetime warranty.

Home of the car

Differences show that the United States urges Israel to adjust its military action strategy in Gaza

　　US Presidential National Security Assistant jack sullivan visited Israel on 14th and met with Israeli Prime Minister Benjamin Netanyahu. With regard to the Israeli military operations in the Gaza, the United States called on Israel to adjust its strategy and turn it into a "low-intensity, high-precision" attack.

　　The United States and Israel have different opinions.

　　△ On December 14th, local time, Israeli Prime Minister Benjamin Netanyahu (right) met with US President’s National Security Adviser jack sullivan (left) in Tel Aviv.

　　John Kirby, strategic communication coordinator of the White House National Security Council, said that Sullivan discussed with Israel the "possible transformation" of Israeli military operations in the Gaza and called on Israel to turn the current "high-intensity" military operations into "low-intensity" precision strikes, but no timetable was set.

　　A senior official of the U.S. government, who asked not to be named, told Reuters that Sullivan’s meeting with Israel and previous high-level meetings and phone calls between the U.S. and Israel did involve discussions on the change of Israeli military strategy, and the U.S. side was more inclined to turn the current "fast-paced, high-intensity" military operations to clear the Palestinian Islamic Resistance Movement (Hamas) into "low-intensity" operations such as targeting high-value targets and launching raids based on intelligence.

　　US President Barack joseph robinette said on the 12th that Israel is losing the support of the international community because of its indiscriminate bombing of Gaza. Biden was asked on 14th whether he hoped the Israeli army would end its military operations before the end of the year. He replied that he hoped the Israeli army would pay more attention to the safety of civilians, not stop attacking Hamas, but "be more careful".

　　However, Israel did not give a clear statement on whether to adjust its military action strategy. During the meeting, Israeli Defense Minister Joyaf galante told Sullivan that the Israeli military action against Hamas "will continue for several months", and Israel will eventually win and destroy Hamas.

　　The Israeli Prime Minister’s Office said in a statement on the 14th: "We will continue to fight more resolutely than ever before until we win an absolute victory in destroying Hamas."

　　The Israeli army continued its offensive

　　△ On December 15th, local time, after the Israeli air raid, smoke billowed over Khan Younis, a city in the south of Gaza.

　　On 14th, the Israeli army continued its military operations in the Gaza, not only intensively bombing several urban areas such as Zaitong in the northern city of Gaza, but also attacking targets such as Khan Younis and Rafah in the southern city. Health authorities in Gaza said that at least 111 people were killed in the air raid that day.

　　Although the Israeli army declared last month that it had basically achieved its military objectives in the northern part of the Gaza Strip, the fighting did not stop. On the 13th, an Israeli army was ambushed in the residential area of Shajaya in the east of Gaza, killing nine people. On the 14th, the Israeli army claimed to have destroyed an Hamas stronghold in a school in Shajaya. In the Gebali refugee camp, Israeli troops attacked a hospital. Health authorities in the Gaza said that the Israeli army detained and abused hospital staff and prevented them from treating the wounded.

　　Earlier this week, Israeli troops invaded the center of Khan Younis, and the whole city was bombed. The Israeli army said on the 14th that it destroyed two tunnel shafts, a rocket launching site and a weapons storage facility in Khan Younis. A number of health officials in the Gaza said that the Israeli army attacked a building in Khan Younis early on the 15th, killing four people and injuring many others, including two children.

　　According to the statistics of the health department in the Gaza, since the new round of Palestinian-Israeli conflict broke out on October 7, Israeli military operations in the Gaza have caused more than 18,600 Palestinian deaths and more than 50,000 injuries.

　　Reuters reported that almost all residents in Gaza were displaced due to the continuing conflict, and many people were forced to move several times. A large number of people are starving. Some people beg for a bite of bread, some people buy a can of beans at 50 times the usual price, and some people stop trucks carrying aid to beg for food.

　　Philip Lazzarini, Director-General of the United Nations Relief and Works Agency for Palestine Refugees in the Near East, said: "There are more and more people we meet who have nothing to eat for one or two or even three days."

BMW X4 Interprets 3.0T+ Automatic Manual Integration (AT)

The competition in the automobile market is still very fierce. What Xiaobian brings today is. Let’s take you to appreciate its style.

Let’s look at the appearance of the BMW X4 first. The front face of the BMW X4 improves the grade of the whole vehicle and looks sporty. Coupled with the round and lovely headlights, it looks quite simple and generous. The car is equipped with LED daytime running lights, automatic opening and closing, adaptive far and near light, automatic steering, delayed closing and so on. Coming to the car side, the car body size is 4762MM*1926MM*1632MM, and the car adopts dignified lines, which gives people a very fashionable and atmospheric feeling. With large-sized thick-walled tires, it looks full of sports. In terms of the rear end, the rear end looks very fashionable, and the taillights show a domineering and stylish design style. Together with the unique exhaust pipe, the sense of neatness is vivid.

Sitting in the car, BMW X4 interior styling is more fashionable and concise, and the overall styling is remarkable. The steering wheel of the car is very in line with the interior style, and it is equipped with the functions of manual steering wheel up and down+front and rear adjustment, steering wheel heating and so on, which is full of design sense. Take a look at the central control. The car is equipped with a touch-sensitive LCD central control screen, which makes the interior design quite layered and conforms to the mainstream aesthetics. Let’s take a look at the dashboard and seats again. The dashboard design is remarkable, and the shape takes the movement route. The car uses leather seats, which are wide and thick, further improving the comfort of drivers and passengers.

BMW X4 is matched with an automatic manual transmission (AT) gearbox, with a maximum power of 245KW and a maximum torque of 500N.m, and its power performance is good.

The car is equipped with car networking, driving mode selection, remote control key, interior atmosphere light, engine start and stop, etc., which is rich in functions and greatly improves its convenience.

This car performs well in terms of space and configuration. As for the design, everyone has everyone’s aesthetics. If you have plans to buy a car now, then today’s car is worth learning about.

Nanning area Cadillac XT5 special sale, discount 130,000! Limited time special offer

[Autohome Nanning Discount Promotion Channel] Bringing you good news, luxury SUVs are going through an unprecedented promotion in the Nanning market. Currently, car buyers can enjoy up to 130,000 yuan in cash, making the XT5 model, which originally started at 242,700 yuan, more affordable. This is a great opportunity not to be missed. If you are interested in the Cadillac XT5, be sure to click "Check the car price" in the quotation form to get the latest market discount information to ensure you can seize this rare discount opportunity.

南宁地区凯迪拉克XT5特价出售，优惠13万！限时特惠

The exterior design of the Cadillac XT5 is unique and exquisite, the front face adopts the family’s signature diamond cutting process, the air intake grille is wide and atmospheric, and the use of chrome trim adds a sense of luxury. The body lines are smooth, and the overall style is both sports and business, hard and elegant. The combination of large-size wheels and tires further enhances the dynamic visual effect of the vehicle. In detail processing, the XT5 highlights Cadillac’s persistent pursuit of quality and design.

南宁地区凯迪拉克XT5特价出售，优惠13万！限时特惠

The Cadillac XT5 presents a side profile of elegance and power, with a body size of 4813mm*1903mm*1682mm and a wheelbase of 2857mm, creating a spacious and comfortable interior. The side lines are smooth, which perfectly blends luxury and sportiness. The front and rear wheel tracks are 1645mm, ensuring driving stability. The tire size is 235/65 R18, and it is matched with a delicate wheel design, which not only enhances the visual effect, but also ensures the grip and comfort on the road.

南宁地区凯迪拉克XT5特价出售，优惠13万！限时特惠

The interior design of the Cadillac XT5 highlights the perfect fusion of luxury and technology. The exquisite leather steering wheel provides a comfortable grip and supports manual up, down, and front and rear adjustments, making it easy for the driver to adjust according to needs. The central control area is equipped with an 8-inch high definition touch screen, which integrates functions such as multimedia systems, navigation, phone and air conditioning, making it easy to operate and intuitive. The seats are made of high-quality imitation leather and leather materials, providing a comfortable and durable ride experience. The front seats support front and rear adjustment, backrest adjustment and lumbar support, and the driver’s seat also has a power seat memory function to ensure the comfort of long driving. The passenger seat is also equipped with a similar multi-directional adjustment function, allowing passengers to adjust the sitting position according to needs. The rear seats not only move back and forth, but also support proportional reclining, providing flexible cargo space. Overall, the interior design of the XT5 is designed to provide a superior ride experience and practicality.

南宁地区凯迪拉克XT5特价出售，优惠13万！限时特惠

The Cadillac XT5 is equipped with a powerful 2.0T engine with a maximum power of 174 kilowatts and a maximum torque of 350 Nm, capable of delivering 237 horsepower. Combined with a sophisticated 9-speed automatic transmission, it provides the driver with a smooth and efficient driving experience.

Overall, the Cadillac XT5 has won high praise from Autohome owners for its domineering appearance and smooth body lines. The petal-shaped wheel design not only enhances the visual appeal of the vehicle, but also perfectly integrates with the body style, showing a full sense of power. As a model that meets the needs and aesthetics of owners, the XT5 is undoubtedly a model of practicality and aesthetics. For consumers who pursue individuality and quality, it is undoubtedly a choice worth considering.

Director Teng Huatao talks about the controversy of ＂Shanghai Fortress＂： I used the wrong Luhan

Directed by Teng Huatao, the domestic sci-fi film starring Lu Han and Shu Qi received a lot of publicity before the release, but encountered the dilemma of word-of-mouth Waterloo after the release. Creator Teng Huatao and the original author Jiangnan came forward one after another and apologized to the audience on Weibo. Teng Huatao also gave another interview to "Poisonous Tongue Movie" a few days ago, responding to the controversy of negative word-of-mouth and the choice of actors. He explained: "I apologize without anyone coercion, nor any commercial purpose, just personal choice." During the conversation, Teng Huatao also talked about one of the film’s huge controversies, Lu Han, saying that he had no opinion on Lu Han technically, but ignored the difference in the type of actors. "I used the wrong Lu Han, in a type that is not suitable for him."

Teng Huatao explained why he "misused" Lu Han, saying that he wanted to make a sci-fi war movie, but ignored Lu Han’s actor type when choosing actors. "I used Lu Han wrong, in a genre that is not suitable for him." It also means that Teng Huatao directly admitted that Lu Han is not suitable for playing sci-fi war themes. In addition, when talking about Jiang Yang (Lu Han’s character) bangs hairstyle, Teng Huatao also frankly: "I think it may be a [problem], but this is an irreversible thing. After the filming is settled, do I have any other possibilities to adjust?"

When asked if he would change actors if there was a possibility of a comeback, Teng Huatao said his intuition was "not that Lu Han is bad, but that we have never made this type of film", and without experience, "can we make Lu Han?"When such an idol went to play, I didn’t judge it well at that time. "

In addition, Teng Huatao also once again refuted the rumor that Lu Han’s sky-high salary, emphasizing that he "received very little money". He said that when he decided to use Lu Han in 2017, he did not take into account some of the opinions that people would have on traffic stars. "Traffic stars are always a double-edged sword." He also denied that he used Lu Han for traffic reasons – the movie tickets that fans can buy are limited in conversion energy.

In the interview, Mr. Teng also noted that the actors were chosen by themselves and were "innocent" and that "it’s not realistic to expect people to say anything [to apologize] when the film doesn’t perform well."

Just this Sunday night! ＂Extreme Challenge＂ Dongguan Station goes LIVE!

Aguan sent it before.

Gong Jun, Huang Jingyu, Huang Minghao, Yan Haoxiang…
<极限挑战>
Recorded in Dongguan! "
It generated a lively discussion and anticipation

Many fans and friends are asking:

When will the feature film be broadcast?!

Today, the official announcement came out!

The main feature of the program will be aired this Sunday (June 2)

Are you all looking forward to it?

The artists who came to Dongguan to record the program this time include

Da Zhang Wei, Gong Jun, Huang Jingyu, Huang Minghao, Huang Xiaoming,

Jia Nailiang, Yan Haoxiang, Zhu Xudan, Guo Xiaoting

During the filming process

On major social platforms

There are already many netizens of Reuters

The source of the picture

You can see it in the preview.

The Extreme Pickup Group conducted a series in Dongguan

Exciting challenge

And feel

Dongguan’s young, dynamic and trendy atmosphere

In this Sunday’s program

And you’re going to see some incredible things.

Wonderful performance at Houjie Mousse Factory

In this intelligent factory

What surprises await them?

The official trailer of the picture source

The extremely picky group will also come to the Houjie Time merchandise block

In this new space full of industrial trends

What "good shows" will they put on here?

The official trailer of the picture source

And not only that.

Dongguan music bus full of musical charm

And extremely challenging group

What kind of trend "spark" will collide?

The official trailer of the picture source

And the extremely picky group in pajamas

"Non-stop" to Xieyuzhou merchandise park

And for what?

The official trailer of the picture source

Looking forward to this Sunday evening (June 2).

Broadcast of "Extreme Challenge" Dongguan Station

Follow in the footsteps of the stars

Let’s explore the infinite charm of Dongguan together

Original title: "Just this Sunday night!" Extreme Challenge "Dongguan Station goes LIVE!"

Read the original text

Jackie Chan, who looks earthy, is actually an idol among idols

Text | Cai Xiaoma

In Jackie Chan’s 43-year film career, he has supported many younger generations, such as Wu Yanzu and Nicholas Tse in "New Police Story" to break through themselves, "Baby Project" to help Gu Tianle transform, and "Private Junior" to director Ding Sheng.

Although there has not been a "successor to Jackie Chan" so far, this has not dampened Jackie Chan’s interest in finding a successor.

So we saw Huang Zitao and Wang Continental in "Flying Tiger" in 16, Li Zhiting and Zhang Yixing in "Kung Fu Yoga" in 17, and then Yang Yang and Allen in "Pioneer", which was delayed until this year.

Did you find it? It’s all a match of two male students.

One focuses on action scenes, the other is responsible for making a fool of himself, and the two together are the most typical Jackie Chan style.

This was the magic weapon that he had used for 40 years in the world, and it was also the wealth he wanted to pass on.

The other side of the world is that netizens don’t buy it.

In their eyes, Jackie Chan’s image on the Chinese Internet is "duang" and shoddy webgame advertisements. It is a "money-making movie" that is not as good as one. It is an earthy man who has no way to teach his son and has no way to stop him. Many people even express doubts about his status as a "big brother", thinking that "Jackie Chan is an acrobat, he knows a fart movie."

Just like the attribute of the Chinese Internet – forgetfulness.

More idols than idols

If you go back in time to Japan 40 years ago, you will see a different look of Jackie Chan.

In the eyes of the Japanese, he is not a reckless man who can only fight. On the contrary, he is a little fresh meat with a jade tree facing the wind and refreshing sunshine.

Even if we don’t talk about kung fu, Jackie Chan’s appearance when he was young was also crushing compared to today’s little fresh meat.

In the 1980s, when CDs first appeared, Jackie Chan was invited to publish CDs in Japan and broke into the top ten of the annual best-selling list in one fell swoop, relying on neither singing skills nor popularity – but it is very different from the current small fresh meat.

And the backless sweater known as the "virgin killer" that was popular a few years ago, the eldest brother had already worn it for photos many years ago.

Not only is she not a mother, but she is also very masculine.

Even through the black silk fishing net see-through outfit, the strong muscles are eye-catching, but they still can’t cover up the heroism and youth between the eyebrows.

In the era when the Japanese male god was still a solemn and strong man like Takakura Jian, a handsome, cute and energetic kung fu boy suddenly emerged, and he had the super combat power of a strong man who could flip the house with a rag. How could it not be fascinating.

This also led to two Japanese female movie fans committing suicide because they saw the fake news of Jackie Chan’s marriage. In that era of underdeveloped information, the eldest brother had such terrible influence.

In Japan, Jackie Chan is regarded as an idol by stars such as Takuya Kimura and Naoto Takenaka, and is used as a prototype and material library by avid fans Akira Toriyama to draw the world’s highest-selling manga "Dragon Ball".

Such a big brother is obviously an idol among idols, how can he now become what some netizens call "acrobatics"?

The director of the Academy Award for Best Picture doesn’t understand movies?

As for the thought that Jackie Chan can only fight and doesn’t understand the film industry, it’s even more funny.

As early as 1979, Jackie Chan wrote, directed and starred in "Laughing Fist". At that time, he had only acted in three films: "Sword Flower and Firestorm Jiangnan", "Serpentine Diao Hand" and "Drunken Fist". "Laughing Fist" won the annual box office championship in Hong Kong that year. The action design has been better than "Drunken Fist", full of new ideas, and initially demonstrated the subtle use of the environment and utensils that will be invincible in the future.

In this film, Big Brother also made his women’s clothing debut, just like Chunli Cosplay in "City Hunter" many years later.

Jackie Chan has written, directed and starred in a total of 16 films, among which "Plan A", "Police Story" and "Miracle" are all classics with good reputation at the box office, and "Major Crime Squad" and "Revolution of 1911" prove that Jackie Chan can also control film genres other than action comedy.

Among them, "Police Story" won the best film at the 5th Academy Awards, "Red Fan District" won the best action design at the 15th Academy Awards, and "Major Crime Squad" was the best actor who won the Golden Horse Award for Jackie Chan, all of which proved that Jackie Chan is a film all-rounder.

After becoming famous in the Chinese world, Jackie Chan tried to introduce his style to the world.

In 1995, with the "Red Fan District" in North America to win $32 million at the box office, successfully entered Hollywood, and then shot in Hollywood, "Rush Hour", "Shanghai Noon" and other action movies, combined with Hollywood’s advanced film industry system, while maximizing the retention of Jackie Chan action comedy style, won a considerable box office in the world.

In the same year, Big Brother won the MTV Lifetime Achievement Award, and he was awarded the award by Quentin Tarantino, a fanatical fan of kung fu movies who has expressed his love for Jackie Chan countless times. His award speech today seems to be a deep confession from a fan girl to a love bean.

He said:

"It’s up to me to present Jackie Chan with the Lifetime Achievement Award, and I feel like being invited to present this award is like getting the Lifetime Achievement Award, because honoring my forever hero is like winning an award yourself.

Watching Jackie Chan’s movies can stimulate physical energy more than other performers. Perhaps soon, you will want to become Jackie Chan, and you also want to run and jump out of the window, but only he can do it. You want to defeat 25 people, even if you start unfavorably but finally knock them all down, but only he can do it. Jumping through glass windows, high-rise buildings, and being thrown by buses can be handled with ease.

He is the best producer in history, world famous, and the best action actor since the talking movies. Seriously, if I could become any actor, I would choose to have Jackie Chan’s acting career.

We’re going to play you a short video now to show you what makes this man so amazing!

Look, what I said is true! Without further ado, the greatest actor in the history of movies – Jackie Chan! "

Twenty-one years later, the Oscars also awarded Jackie Chan the Lifetime Achievement Award to his old "Rush Hour" co-star Chris Tucker, an award that only two East Asians had won before: Akira Kurosawa, the "film emperor," and Hayao Miyazaki, the living legend of animation.

The award was given to Jackie Chan, and of course he deserved it. Feng Xiaogang even said that "Brother Jackie Chan won the Oscar, that’s his honor for the Oscar."

"Thank you Hollywood," Jackie Chan said after receiving the Oscar for lifetime achievement. "You taught me a lot over the years and made me a little famous filmmaker."

Well, ordinary and unremarkable Gu Tianle, a little famous Jacky Chen.

You think Jackie Chan is in the first layer, but in fact, the eldest brother is in the atmosphere

Users have only seen Jackie Chan’s endorsement of webpage games, and crazy filming is just for bad money. This is the first layer.

Film critics have seen the decline and lack of successors of the entire Hong Kong kung fu film, which is only the second level.

Only the eldest brother is the man who truly stands in the atmosphere.

The kung fu film has declined, and the one who has been most affected is still the martial artist who relies on this to eat. Jackie Chan’s direct disciple Fan Shaohuang is dedicated to the Internet University; Zhang Jin has made cameo appearances everywhere to play villains, but there is never a play to let everyone remember; Shi Xiaolong is only familiar with Douyin.

However, the eldest brother who raised a whole family behind him was like a subway line that was not noticed. It seemed to be losing money every year, but it actually drove the development of a series of industries and changed the ecological environment of the entire film industry.

Li Zhongzhi Huang Weiliang, who came out of the Chengjia class, jointly served as the martial arts instructor of the "Wolf Warrior" series. The martial fingers of "Operation Red Sea" and "Operation Mekong River" are also Huang Weiliang; the martial fingers of "Evil is Not Pressure" are He Jun, Chengjia class; "Let Bullets Fly" refers to Xue Chunwei, Chengjia class; "Dragon Gate Flying Armor" and "Climber" refer to Wu Yonglun, Chengjia class; "Pacific Rim", "Ace Agent" and "Wonder Woman" refer to Bradley, although he is a white person, he also graduated from Chengjia class.

What Big Brother has been doing these years is actually cultivating good seeds for the Chinese language and even the world film industry. Generations of family members have entered every corner of the film industry, standing behind the scenes, working hard to show their achievements, thinking about their own path, and continuously pumping blood for the survival and development of the action film genre.

Big brother is not in the atmosphere, who is in the atmosphere?

Without the big brother’s protection, I’m afraid it’s not that traditional kung fu movies will decline, but that entire action movies and even dramas with some action elements will stagnate or even go back 20 years.

It is said that a certain female love bean is a beautiful girl once in 4000 years, so with such contributions, I can praise Jackie Chan as a once-in-5000-year kung fu superstar, isn’t it too much?

Big brother will always be your big brother

However, it is a pity that no matter what kind of praise and worship Jackie Chan receives abroad, on the Chinese Internet, it is the evaluation of "nothing new" and "eating old".

It seems that many people have forgotten the contributions he has made, and they have not seen the innovations and attempts he has made in new films today at the age of nearly 70.

He is still the big brother, still wears Tang clothes everywhere, and talks about "I’m Chinese". He also really loves this country and is worried about the big brother of Chinese culture going out.

Looking back, the cute and lively Jackie Chan in "Drunken Fist" has not changed at all in his 43-year film career. He is more like the unaltered teenager than anyone else, with a childlike innocence and curiosity about the world, burning his life.

This man, who was not understood by others, took on more and more responsibilities and moved forward firmly as always.